研究内容の紹介です　Laboratory of Histopathology and Cytopathology Gunma University Graduate School of Health Sciences

We would like to introduce our research.

We conduct a wide range of research in the fields of pathology, pathological testing, and cytodiagnostics. The main research themes are introduced below.

Newly published papers are updated on BIBLIOGRAPHY, so please take a look.

---

Analysis of cell biological mechanisms of nuclear shape change.

When cancer occurs, the nucleus of a cell becomes enlarged or distorted. However, this is completely different depending on the type of cancer cell. For example, in cancer of the secretory gland (adenocarcinoma), a constriction is formed in the nucleus, but in cancer of stacked cells called stratified squamous epithelium, the constriction is not noticeable. We use computers to analyze the nuclear shapes of various cancer cells. In the near future, we are currently working hard to analyze factors that change the size and shape of nuclei in cultured cells using cell biological and molecular biological methods.

---

Molecular pathological analysis of "Cell in Cells phenomenon"

The phenomenon in which a cell enters a cell while still alive is collectively called the "cell in cell phenomenon." To date, various phenomena such as emperipolesis, cannibalism, and entosis have been intensively studied in world research, but we are currently studying this "cell in cell phenomenon" in which cells are engulfed within cells. We use diagnostic specimens, pathological tissue specimens, etc., and analyze them using computer-based image analysis. Furthermore, in the near future, we are preparing to explore factors that promote and suppress cell in cell phenomena using cultured cells.

---

Molecular pathological analysis of liver and lung fibrosis

When an organ is destroyed, the human body tries to fill the hole by creating hard, thread-like substances called fibers before regenerating the destroyed cells. For example, when a hepatitis virus infects liver cells and destroys them, fibers surround the remaining liver cells. Unfortunately, when these fibers surround liver cells, they cut off the sinusoids, the channels through which blood flows, which are located next to the liver cells. This is a disease called liver fibrosis or cirrhosis. When this occurs in the lungs, it is called pulmonary fibrosis.We stain tissues in cases of liver cirrhosis and pulmonary fibrosis using special staining and immunostaining methods often used in pathology, and then use a computer to determine the area of fibrosis. Analyzing density etc.

Research on improving the accuracy of pathological specimens

We are conducting research to improve the accuracy of pathological specimens. Cutting a specimen into thin pieces is called slicing, and we are researching what conditions should be used when slicing specimens. I plan to report on this as data becomes available in the future.

---